Global gene expression analysis at successive stages of carcinogenesis revealed hallmarks linked to tumour size. We used the murine MG U74Av2 oligonucleotide microarrays to identify transcript signatures in 12 tumours of small (n=5, pooled), medium (n=4) and large sizes (n=3), and compared the findings with three nontumorous transgenic livers and four control livers. Targeted overexpression of IgEGF induced distinct hepatocellular lesions and eventually solid tumours at the age of 6-8 months, as evidenced by histopathology. To identify the network of genes regulated through EGF, we investigated the liver transcriptome during various stages of hepatocarcinogenesis in EGF2B transgenic mice.
Its overexpression promotes hepatocellular carcinogenesis. Genes up-regulated in hepatocellular carcinoma (HCC) developed by transgenic mice overexpressing a secretable form of EGF in liver.Įpidermal growth factor is an important mitogen for hepatocytes. Thanks in advance for your help and support.įor the Human gene set with the same name, see BORLAK_LIVER_CANCER_EGF_UP Standard name Why you chose it over other tools, and your view of its current impact and future promise, will go a long way in underscoring their To help ensure their continuing availability, we would greatly appreciate your email of support to accompany our submission.Ī short email telling us, for example, how you use GSEA/MSigDB in your work, especially in cancer related projects, We are preparing a grant proposal to NCI's Information Technology for Cancer Research programįor the continued funding of GSEA and MSigDB.Ĭlick here to learn how you can help.
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